許韌

醫(yī)學博士后、教授、博士生導師，細胞應激生物學國家重點實驗室課題組長,“閩江學者”特聘教授，國際華人骨研學會終身會員、美國和日本骨代謝學會會員、獲得中國駐日本大使館-中國學友會會長榮譽證書、日本文部?。ń逃浚?全球杰出計劃-“超級學生” 稱號、國際華人骨研學會（ICMRS）Webster Jee青年學者獎、國際骨免疫年會-青年學者獎、美國骨代謝研究學會（ASBMR）青年學者獎、美國骨研究促進會（AIMM）John Haddad青年學者獎、廈門大學“南強青年拔尖人才”-A類、中組部青年千人-會評（新冠疫情延期中）。近年來，骨骼系統與機體其他組織/器官之間的偶聯機制逐漸成為系統生物學研究的新興熱點，也是進行精準醫(yī)學治療所必須明確的核心內容。許韌博士一直聚焦于骨形成細胞與其支撐系統的交流機制，深入探究成骨微環(huán)境的調控功能和潛在的臨床價值。其中以第一作者身份在Nature、Nature Medicine和JBMR等國際知名期刊上均發(fā)表研究成果。

目前實驗室致力的主要研究方向如下：

1）骨特異性神經/血管體系在骨骼退行性疾病中的作用機制

2）成骨細胞來源細胞因子在機體能量代謝中的功能

3）骨骼干細胞/前體細胞在癌癥發(fā)生和骨轉移中的介導機制

主持科研項目

1. 國家自然科學基金面上項目（8197090543），2020/01-2023/12，SLIT3介導的血管亞型在骨骼干細胞微環(huán)境中的作用機制研究，￥550,000，主持

2.廈門大學“南強青年拔尖A類人才”啟動經費，￥3,000,000，主持

3.CornellUniversity-FFPI Grant, “Identification of Novel Mediators Governing Osteoblast-Type H Endothelial Cells Coupling”, 2015-2017，$100,000，主持.

已申請的專利：

美國專利：Matthew Greenblatt,Ren Xu and Laurie Glimcher, SLIT and Bone Growth Modulation (Filing, US 62/630,557) 2018

主要相關論著：

1.Li N, InoueK, Sun J, Niu Y, Lalani S, Yallowitz A, Yang X, Zhang C, Shen R, Zhao B,Xu R#, Greenblatt MB. Osteoclasts Are Not a Source of SLIT3. Bone Res. 2019 .

2.Ji G*,Xu R*, Niu Y, Li N, Ivashkiv L, Bostrom MPG, Greenblatt MB, Yang X. Vascular endothelial growth factor pathway promotes osseointegration and CD31(hi)EMCN(hi) endothelium expansion in a mouse tibial implant model: an animal study.Bone Joint J. 2019 Jul;101-B:108-114.

3.Xu R, Yallowitz A, Qin A, Wu Z, Shin D, Kim J, Debnath S, Ji G, Bostrom M, Yang X, Zhang C, Dong H, Kermani P, Lalani S, Li N, Liu Y, Poulos M, Wach A, Zhang Y, Inoue K, Lorenzo A, Zhao B, Butler J, Shim J, Glimcher L and Greenblatt MB. Targeting skeletal endothelium to ameliorate bone loss.Nature Medicine 2018 Jun;24(6):823-833.

4.Debnath S, Yallowitz A, McCormick J, Lalani S, Zhang T,Xu R, Li N, Liu Y, Yang Y, Eiseman M, Shim J, Hameed M, Healey J, Bostrom M, Landau D, Greenblatt MB. Discovery of a periosteal stem cell mediating intramembranous bone formation and fracture healing.Nature 2018 Oct;562(7725):133-139.

5. Inoue K, Deng Z, Chen Y, Giannopoulou E,Xu R, Gong S, Greenblatt MB, Mangala LS, Lopez-Berestein G, Kirsch DG, Sood AK, Zhao L, Zhao B. Bone protection by inhibition of microRNA-182.Nat Commun. 2018 Oct 5;9(1):4108.

6.Ji G, Han A, Hao X, Li N,Xu R, Wang F. Better rotational control but similar outcomes with the outside-in versus the transtibial drilling technique foranterior cruciate ligament reconstruction: a systematic review of comparativetrials.Arch Orthop Trauma Surg. 2018 Nov;138(11):1575-1581.

7.Xu R, Zhang C, Shin DY, Kim JM, Lalani S, Li N, Yang YS, Liu Y, Eiseman M,Davis RJ, Shim JH, Greenblatt MB. c-Jun N-terminal kinases (JNKs) are criticalmediators of osteoblast activity in vivo.J Bone Miner Res. 2017 Sep;32(9):1811-1815.

8.Ma C, Fukuda T, Ochi H, Sunamura S, Xu C,Xu R, Okawa A, Takeda S. Genetic determination of the cellular basis of the ghrelin-dependent bone remodeling.Mol Metab. 2015 Jan 21;4(3):175-85.

9.Xu R#. Semaphorin 3A: A new player in bone remodeling.Cell Adh Migr. 2014;8(1):5-10. Review.

10.Fukuda T*, Takeda S*,Xu R*, Ochi H, Sunamura S, Sato T, Shibata S, Yoshida Y, Gu Z, Kimura A, Ma C, Xu C, Bando W, Fujita K, Shinomiya K, Hirai T, Asou Y, Enomoto M, Okano H, Okawa A, Itoh H. Sema3A regulates bone-mass accrual through sensory innervations.Nature 2013 May 23;497(7450):490-3.

11.Wang M, Liu S, Li Y,Xu R, Lu C, Shen Y. Protoplast mutation and genome shuffling induce the endophytic fungusTubercularia sp. TF5 to produce new compounds.Curr Microbiol. 2010 Oct;61(4):254-60.

12. Inose H, Ochi H, Kimura A, Fujita K,Xu R, Sato S, Iwasaki M, Sunamura S, Takeuchi Y, Fukumoto S, Saito K, Nakamura T, Siomi H, Ito H, Arai Y, Shinomiya K,Takeda S. A microRNA regulatory mechanism of osteoblast differentiation.Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20794-9.

13.Xu R, Wang M, Lu C, Shen Y. Tuberculariol A – C, new sesquiterpenes from mutant-741 ofTubercularia sp. TF5.Helv Chim Acta. 2009;92:1514-19.

14.Xu R, Lu C, Wu X, Lin C and Zheng Z. A new ten-membered lactone fromTubercularia sp. TF5, an endophytic fungus ofTaxus mairei.Chem. Nat. Compd. 2009;45; 6.